Instaflex Advanced: Reviewing the Joint Health Support Formula (2024)

Instaflex Advanced is a nutritional supplement that claims to relieve joint pain. Joint pain supplements are increasingly common in the supplement industry, so we recommend that consumers research all claims of joint pain relief extensively before purchasing a product.

Instaflex Advanced is one of the best-known and most-studied joint supplements available today. You can find the supplement for purchase on Amazon, at Walgreens and RiteAid, and many other retailers. Instaflex has even gone through clinical trials, which seem to definitively support the benefits claimed by its creators.

Should you buy Instaflex Advanced? Is Instaflex Advanced the right choice for you? Let’s take a closer look at everything you need to know about Instaflex Advanced and how it works in our comprehensive product review.


What is Instaflex Advanced?

Instaflex Advanced: Reviewing the Joint Health Support Formula (1)

Instaflex Advanced is a nutritional supplement that claims to be doctor-formulated to relieve discomfort, improve flexibility, and provide relief from joint pain in just 7 days.

The supplement is priced at around $60 per bottle, with 30 capsules (30 servings) in each bottle.

Each capsule contains collagen, turmeric, resveratrol, and boswellia serrata extract. The combination of collagen and herbal extracts will purportedly reduce joint pain. Ingredients like turmeric, for example, have proven antioxidant and anti-inflammatory effects, while ingredients like UC-II collagen are prized for their ability to lubricate joints.

Notably, Instaflex claims to reduce joint pain without glucosamine or chondroitin. These two ingredients are commonly found in all other joint pain supplements. Glucosamine and chondroitin work for some people – but not others.

Overall, Instaflex Advanced claims to target the root cause of joint discomfort, claiming you’ll be able to feel the difference within days.

How Does Instaflex Advanced Work?

Instaflex Advanced: Reviewing the Joint Health Support Formula (2)

Instaflex Advanced contains five active ingredients, including collagen and five herbal extracts. The active ingredients include:

200mg of Turmeric: Turmeric is a proven anti-inflammatory and antioxidant prized for its ability to reduce inflammation throughout the body, which could reduce the risk of disease.

100mg of Resveratrol: Resveratrol is a plant-based antioxidant found in red wine, grapes, and berries. Many people take resveratrol for its antioxidant benefits. Resveratrol is part of a group of compounds called polyphenols, and there’s some evidence they protect you against disease and inflammation.

100mg of Boswellia Serrata Extract: Instaflex uses an herbal extract called Boswellia serrata (from a trademarked formula called Apresflex). There’s some evidence that 100mg of boswellia serrata extract can reduce joint pain and provide other crucial benefits.

40mg of UC-II Collagen: Collagen is one of the trendiest nutritional supplements in recent years. Collagen is the most abundant protein in the body, and it’s associated with anti-aging benefits. Many people take collagen protein supplements to reduce joint pain, support recovery after exercise, or provide anti-aging benefits. Instaflex contains just 40mg of UC-II collagen in each serving, however, which is more lower than the dose found in collagen protein powders.

5mg of Hyaluronic Acid: Hyaluronic acid lubricates joints. You can find hyaluronic acid in plenty of anti-aging supplements. It’s also found in certain skin creams. Applied topically or orally, hyaluronic acid may support anti-aging benefits – including joint health.

Overall, Instaflex Advanced seems to use the right ingredients, including well-studied compounds like turmeric, resveratrol, and collagen.

However, the dosages seem lower than what we’ve seen in other supplements.

You can find hyaluronic acid supplements with 100mg of hyaluronic acid per capsule, for example, for under $10, or resveratrol supplements with 500mg of resveratrol per capsule for around $40. Instaflex Advanced's dosages seem a bit low compared to other supplements – which is surprising given the high price.

Instaflex Ingredients

Instaflex Advanced: Reviewing the Joint Health Support Formula (3)

The full Instaflex Advanced ingredients label is available online. The formula contains no proprietary formulas or hidden ingredients. You can view everything on the label:

Scientific Evidence for Instaflex Advanced

Instaflex Advanced is one of the few joint supplements that has gone through clinical trials to verify its effectiveness. Researchers at Appalachian State University published a clinical trial in 2013. In that trial, researchers assessed the effects of Instaflex Advanced over an 8-week period.

In a double-blind, placebo-controlled trial, participants received either a placebo or Instaflex Advanced. Neither the researchers nor the participants knew what they were taking.

The trial involved 110 participants who had reported conditions like joint pain, stiffness, and impaired joint function.

After 8 weeks of supplementation, here’s how researchers concluded the study:

“Results from this randomized, double blind, placebo-controlled community trial support the use of the Instaflex™ dietary supplement in alleviating joint pain severity in middle-aged and older adults, with mitigation of difficulty performing daily activities most apparent in subjects with knee pain.”

The results of the trial were published in November 2013. You can view the study here.

Individual ingredients in Instaflex Advanced have also been studied, although the dosages seem low compared to most studies. Multiple studies have indicated that turmeric has anti-inflammatory benefits, for example, although all of these studies used 500mg to 2,000mg of turmeric per day, and there’s only 200mg of turmeric in each capsule of Instaflex.

Who’s Behind Instaflex?

Instaflex was created by a company named Adaptive Health. That company makes a variety of supplements, and you can find Adaptive Health supplements at GNC, Walgreens, The Vitamin Shoppe, Amazon, and other major retailers.

The Instaflex Advanced was formulated by Dr. David Katz, Director and Co-Founder of the Yale Prevention Research Center and Director of Integrative Medicine at Griffin Hospital. the supplement was developed in Massachusetts and Utah, and it’s made in a GMP-certified facility.

You can contact the company via the following:

  • Phone: 1-800-436-0920
  • Mailing Address: 2323 South 3600 West West Valley City, UT 84119

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Frequently Asked Questions About Instaflex Advanced

With so many ineffective or scam joint pain supplements in the industry, it's necessary to constantly challenge and question the claims of companies purporting to solve your joint pain. This section will answer many of the most commonly asked questions about Instaflex Advanced, as well as the company and science backing it.

Q: What can Instaflex do?

A: Instaflex is a supplement that might be able to help you decrease the severity and consistency of your joint pain. Joint inflammation and chronic joint pain are incredibly common and often difficult to treat. Solving joint pain can lead to a number of additional benefits to generally wellness and happiness, especially considering how debilitating joint pain can be.

Q: How do you use Instaflex?

A: For the best results, take one capsule of this supplement each day. As always, we recommend that you take any dietary supplement consistently over an extended period of time in order to maximize your chances of seeing positive impacts. It is not clear whether or not you should take this supplement with water or food.

Q: Is Instaflex scientifically supported?

A: Instaflex stands out to us as one of the few joint pain and inflammation supplements in the industry that has actually gone through its own clinical trials. These trials have consistently backed the efficiency claims that the company makes.

Q: Who produces Instaflex?

A: This product is being manufactured and marketed primarily by Adaptive Health, a supplement and wellness company created by Dr. David Katz of Griffin Hospital. The products made by this company are crafted within a GMP-certified facility and the organization has been praised for its clean and transparent production process.

Instaflex Advanced Pricing

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Instaflex Advanced is priced at around $60 per bottle, depending on where you order.

1 Bottle (30 Capsules / 30 Servings): $58 to $60

The official website also sells a trial package for $5. The customer has 18 days to try the sample and must contact the company to cancel the auto-shipment, otherwise the customer will receive a 30-day supply of Instaflex® Advanced and be charged $69.99 plus $4.99 shipping and processing and tax if applicable, to cancel contact customer service at 1-800-436-0920 to receive an RMA number to return the products.

You can try Instaflex Advanced, and see how it works for you, and decide if you want to order a full bottle.

Some retailers sell a 14-capsule bottle for $35. The smaller bottle contains 14 capsules (14 servings) but is otherwise identical to the main Instaflex supplement bottle.

Instaflex Refund Policy

Instaflex Advanced has a different refund policy depending from where you purchased it. Generally, you should be able to return the supplement within 30 days for a full refund if you are unsatisfied with the results. To contact the company behind Instaflex call Phone Support at 1-800-436-0920 Seven days a week 24 hours a day.

Final Thoughts

Instaflex, also known as Instaflex Advanced, is a nutritional supplement that claims to reduce joint pain in just days. The supplement contains ingredients like turmeric, collagen, and resveratrol. You take the supplement daily, and the ingredients reduce joint pain within days.

If you have joint pain and did not experience relief with glucosamine/chondroitin supplements, then Instaflex may be an alternative. The supplement contains no glucosamine or chondroitin, and it supports joint health in other ways. Collagen can enhance lubrication of skin tissue, for example, while turmeric provides antioxidant and anti-inflammatory benefits.

To learn more about and buy Instaflex Advanced, visit the Amazon page today.

Instaflex Advanced: Reviewing the Joint Health Support Formula (2024)


Does Instaflex really work for your joints? ›

Indeed a properly controlled double-blind randomized trial at Appalachian State University showed that those taking Instaflex reported a 37 percent reduction in joint pain. The placebo group reported a 16 percent reduction in pain.

Are there any side effects of taking Instaflex? ›

This 8-week randomized, double-blind, placebo-controlled study with 100 community adults reporting joint pain showed that Instaflex is efficacious and safe to use, with no adverse symptomology or negative effects on general metabolism and liver and kidney function.

How long does it take for Instaflex to start working? ›

How long does it take for Instaflex® Extra Strength Pain Relief Cream to work? This product provides powerful pain relief starting in minutes and lasts for hours.

What is the number one rated joint supplement? ›

Research by the Arthritis Foundation shows things like glucosamine supplements can be as effective for knee issues as anything you would get from your healthcare provider. After doing our own research, it is our opinion that FlexAgain is easily the top supplement of its kind on the market in 2024 for most people.

Does Instaflex affect your kidneys? ›

Long-term use and high doses of Instaflex D Capsule may cause renal problems such as protein or blood in urine and painful urination.

Is Instaflex FDA approved? ›

More Info For This Drug

DISCLAIMER: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Can you take Instaflex every day? ›

Each pill delivers a carefully selected combination of eight key ingredients that have been clinically studied for maximum effectiveness. Use Instaflex daily for a happy, healthy, active life.

What joint supplement should you avoid? ›

Because glucosamine products might be derived from the shells of shellfish, there is concern that the supplement could cause an allergic reaction in people with shellfish allergies. Glucosamine might worsen asthma. There's some concern that glucosamine might raise eye pressure.

Does Instaflex interfere with other medications? ›

Instaflex D 145.6 MG Capsule may rarely cause agranulocytosis; use caution with clozapine and carbamazepine; may decrease the clearance of lithium resulting in elevated serum levels and potential toxicity; monitor serum lithium levels.

What is equivalent to Instaflex? ›

Instaflex's competitors and similar companies include Theraworx Relief, Supp, Metabolic Maintenance and Amazing Herbs. Instaflex is a brand of Adaptive Health offering supplements designed to promote healthy joints, bones, and muscles. Theraworx Relief is a foam that relieves muscle cramps provided by Avadim Health.

Does Instaflex have collagen in it? ›

Instaflex Advanced Featuring UC-II Collagen | Walgreens.

Does Instaflex help your back? › Customer reviews: Instaflex Pain Relief Cream Delivers Clinically Studied Pain Relief from Arthritis, Back Pain, Strains and Joint and Muscle Pain (2 oz)

Which is better for joint pain, turmeric or glucosamine? ›

Both turmeric and glucosamine chondroitin offer unique benefits for pain relief and joint health. Combining them may provide a synergistic effect, enhancing their individual properties and potentially improving overall pain management.

Is there a joint supplement that really works? ›

The best supplements for alleviating joint pain include turmeric, fish oil, collagen, chondroitin and glucosamine. Keep in mind that the best supplement for you depends on factors like your health history, your symptoms and any medications you're taking.

What vitamin am I lacking if my joints hurt? ›

A vitamin D deficiency can affect both physical and mental health, but many people have low levels of vitamin D without realizing. The physical symptoms of a deficiency may include muscle pain in the joints, including rheumatoid arthritis (RA) pain, which often occurs in the knees, legs, and hips.

What is the best product to take for joint pain? ›

Nonsteroidal anti-inflammatory drugs or NSAIDs. OTC doses of these drugs, including ibuprofen (Advil, Motrin IB) and naproxen sodium (Aleve), may be useful for relieving pain.

How many times a day do you take Instaflex? ›

Adult Usage: Take one (1) capsule daily, with or without food.

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